General Information
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DRAMP ID
DRAMP02091
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Peptide Name
Brevinin-1Ba (Frogs, amphibians, animals)
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Source
Rana berlandieri (Rio Grande leopard frog)
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Family
Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
Unknown
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Sequence
FLPFIAGMAAKFLPKIFCAISKKC
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Sequence Length
24
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Swiss_Prot Entry
P82833
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Evidence code
Protein level
Activity Information
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Biological Activity
Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
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Target Organism
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- [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=2 μM).
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Hemolytic activity
- Unknown
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Binding Target
Unknown
Structure Information
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Structure
Unknown
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Structure Description
Unknownn
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PDB ID
Unknown
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Physical Information
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Formula
C128H202N28O26S3
Absent Amino Acids
DEHNQRTVWY
Common Amino Acids
AFK
Mass
3055.81
PI
10.35
Basic Residues
4
Acidic Residues
0
Hydrophobic Residues
13
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Boman Index
24.01
Hydrophobicity
110
Aliphatic Index
97.92
Half Life
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- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
125
Absorbance 280nm
5.43
Polar Residues
4
DRAMP02091

Comments Information
Function
Antibacterial activity against Gram-positive bacteria.
Tissue specificity
Expressed by the skin glands.
Literature Information
- Literature 1
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Pubmed ID
10651828
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Reference
Eur J Biochem. 2000 Feb;267(3):894-900.
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Author
Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
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Title
Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.