General Information
-
DRAMP ID
- DRAMP02098
-
Peptide Name
- Brevinin-1Pc (Frogs, amphibians, animals)
-
Source
- Rana pipiens (Northern leopard frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FLPIIASVAAKVFSKIFCAISKKC
-
Sequence Length
- 24
-
UniProt Entry
- P82843
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=7 μM);
- Gram-negative bacterium: Escherichia coli (MIC=5 μM).
- Yeast: Candida albicans (MIC=7 μM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP02098_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C123H202N28O28S2
Absent Amino Acids
- DEGHMNQRTWY
Common Amino Acids
- AIK
Mass
- 2585.25
PI
- 9.7
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 14
Net Charge
- +4
-
Boman Index
- 19.02
Hydrophobicity
- 1.3
Aliphatic Index
- 122.08
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 5.43
Polar Residues
- 5
DRAMP02098
Comments Information
Function
- Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
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Pubmed ID
- 10651828
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Reference
- Eur J Biochem. 2000 Feb;267(3):894-900.
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Author
- Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.