• DRAMP ID

    • DRAMP02101
    • Peptide Name

    • Brevinin-1RTa (Frogs, amphibians, animals)
    • Source

    • Amolops ricketti (Chinese sucker frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLPLLAGVVANFLPQIICKIARKC
    • Sequence Length

    • 24
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.3 µg/ml), Bacillus licheniformis X39 (MIC=25.0 µg/ml), Rhodococcus rhodochrous X15 (MIC=3.1 µg/ml);
      • Gram-negative bacteria: Serratia rubidaea X01 (MIC=NA µg/ml), Pseudomonas aeruginosa 1.50 (MIC=NA µg/ml), Psychrobacter faecalis X29 (MIC=12.5 µg/ml).
    • Hemolytic Activity

      • [Ref.22100518]LD50=100 μg/ml against rabbit red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02101 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02101.
    • Formula

    • C124H207N31O27S2
    • Absent Amino Acids

    • DEHMSTWY
    • Common Amino Acids

    • L
    • Mass

    • 2628.32
    • PI

    • 9.5
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 14
    • Net Charge

    • +3
    • Boman Index

    • 19.21
    • Hydrophobicity

    • 1.258
    • Aliphatic Index

    • 150.42
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 4

DRAMP02101

DRAMP02101 chydropathy plot
    • Function

    • Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells (LD50=100.0 µg/ml) in vitro.
    • PTM

    • Contains one disulfide bond 27-33.
  • ·Literature 1
    • Title

    • Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae).
    • Reference

    • Peptides. 2012 Jan;33(1):27-34.
    • Author

    • Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J.