General Information

    • DRAMP ID

    • DRAMP02118

    • Peptide Name

    • Raniseptin-5 (Rsp-5; Frogs, amphibians, animals)

    • Source

    • Hypsiboas raniceps (Chaco tree frog) (Hyla roeschmanni)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • Not found

    • Sequence

    • AWLDKLKNLGKVVGKVALGVVQNYLNPRQ

    • Sequence Length

    • 29

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02118 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02118.

Physicochemical Information

    • Formula

    • C148H246N42O38

    • Absent Amino Acids

    • CEFHIMST

    • Common Amino Acids

    • LV

    • Mass

    • 3221.84

    • PI

    • 10.17

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • -23.41

    • Hydrophobicity

    • -0.086

    • Aliphatic Index

    • 124.14

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 249.64

    • Polar Residues

    • 7

DRAMP02118

DRAMP02118 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity (By similarity).

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Post-secretory events alter the peptide content of the skin secretion of Hypsiboas raniceps.

    • Reference

    • Biochem Biophys Res Commun. 2008 Dec 26;377(4):1057-1061.

    • Author

    • Magalhães BS, Melo JA, Leite JR, Silva LP, Prates MV, Vinecky F, Barbosa EA, Verly RM, Mehta A, Nicoli JR, Bemquerer MP, Andrade AC, Bloch C Jr.