General Information

    • DRAMP ID

    • DRAMP02123

    • Peptide Name

    • Hylin-b1 (Hy-b1; Frogs, amphibians, animals)

    • Source

    • Hyla biobeba (Brazilian tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FIGAILPAIAGLVHGLINR

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.15638808]Show hemolytic activity against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02123 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02123.

Physicochemical Information

    • Formula

    • C92H153N25O21

    • Absent Amino Acids

    • CDEKMQSTWY

    • Common Amino Acids

    • I

    • Mass

    • 1945.38

    • PI

    • 9.76

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • 23.49

    • Hydrophobicity

    • 1.463

    • Aliphatic Index

    • 174.74

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02123

DRAMP02123 chydropathy plot

Comments Information

    • Function

    • Has hemolytic activity against human erythrocytes. May have antimicrobial activity.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Hylins: bombinins H structurally related peptides from the skin secretion of the Brazilian tree-frog Hyla biobeba.

    • Reference

    • Protein Pept Lett. 2005 Jan;12(1):89-93.

    • Author

    • Castro MS, Matsushita RH, Sebben A, Sousa MV, Fontes W.