General Information
-
DRAMP ID
- DRAMP02124
-
Peptide Name
- Hylin-b2 (Hy-b2; Frogs, amphibians, animals)
-
Source
- Hyla biobeba (Brazilian tree frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- FIGAILPAIAGLVGGLINR
-
Sequence Length
- 19
-
UniProt Entry
- P84003
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- [Ref.15638808]Show hemolytic activity against human red blood cells
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02124.
Physicochemical Information
-
Formula
- C88H149N23O21
Absent Amino Acids
- CDEHKMQSTWY
Common Amino Acids
- GI
Mass
- 1865.29
PI
- 9.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +1
-
Boman Index
- 29.09
Hydrophobicity
- 1.611
Aliphatic Index
- 174.74
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP02124
Comments Information
Function
- Has hemolytic activity against human erythrocytes. May have antimicrobial activity.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
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Title
- Hylins: bombinins H structurally related peptides from the skin secretion of the Brazilian tree-frog Hyla biobeba.
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Pubmed ID
- 15638808
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Reference
- Protein Pept Lett. 2005 Jan;12(1):89-93.
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Author
- Castro MS, Matsushita RH, Sebben A, Sousa MV, Fontes W.