General Information

    • DRAMP ID

    • DRAMP02126

    • Peptide Name

    • Melittin-like peptide (MLP; Frogs, amphibians, animals)

    • Source

    • Rana temporaria (European common frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FIGSALKVLAGVLPSIVSWVKQ

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Defense response, Anti-cancer, Protein kinase inhibitor activity

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.9022710] LC=0.5 µM against human red blood cells. (LC: Lethal concentration)

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02126 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02126.

Physicochemical Information

    • Formula

    • C111H182N26O27

    • Absent Amino Acids

    • CDEHMNRTY

    • Common Amino Acids

    • V

    • Mass

    • 2312.82

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +2

    • Boman Index

    • 24.73

    • Hydrophobicity

    • 1.209

    • Aliphatic Index

    • 150.45

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 261.9

    • Polar Residues

    • 5

DRAMP02126

DRAMP02126 chydropathy plot

Comments Information

    • Function

    • Peptide has cellular defense response, inflammatory response, behavioral defense response, defense response to tumor cell, defense response by callose deposition, clearance of foreign intracellular nucleic acids, innate immune response, defense response by cell wall thickening, defense response to other organism, protein serine/threonine kinase inhibitor activity, calcium-dependent protein kinase inhibitor activity, protein tyrosine kinase inhibitor activity in GO analysis. Has hemolytic activity.

    • PTM

    • Glutamine amide at position 22.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • Temporins, antimicrobial peptides from the European red frog Rana temporaria.

    • Reference

    • Eur J Biochem. 1996 Dec 15;242(3):788-792.

    • Author

    • Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.