• DRAMP ID

    • DRAMP02129
    • Peptide Name

    • Kasstasin (Frogs, amphibians, animals)
    • Source

    • Kassina maculata (African rhacophorid frog) (Hylambates maculatus)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FIKELLPHLSGIIDSVANAIK
    • Sequence Length

    • 21
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.21624426]Gram-positive bacterium: Staphylococcus aureus (MIC=55 µM);
      • Gram-negative bacterium: Escherichia coli (MIC=110 µM).
    • Hemolytic Activity

      • [Ref.21624426]12.8% hemolytic activity at 125 μM against defibrinated horse blood
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02129 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C106H176N26O29
    • Absent Amino Acids

    • CMQRTWY
    • Common Amino Acids

    • I
    • Mass

    • 2278.72
    • PI

    • 6.75
    • Basic Residues

    • 3
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +1
    • Boman Index

    • 1.29
    • Hydrophobicity

    • 0.71
    • Aliphatic Index

    • 153.33
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP02129

DRAMP02129 chydropathy plot
    • Function

    • Peptide with potent vasoconstrictor properties. Has moderate antimicrobial activity. Not active against fungus C. albicans. Has hemolytic activity against horse erythrocytes.
    • Tissue specificity

    • Expressed by the skin dorsal glands.
    • Miscellaneous

    • Kasstasin is a derivation of Kassina, the taxon of origin, and the Ancient Greek word 'stasis' meaning 'stoppage of flow'.
  • ·Literature 1
    • Title

    • Kasstasin: A novel potent vasoconstrictor peptide from the skin secretion of the African red-legged running frog, Kassina maculata.
    • Reference

    • Biochimie. 2011 Sep;93(9):1537-1542.
    • Author

    • Li X, Feng W, Zhou M, Ma C, Chen T, Zeller M, Hornshaw M, Wang L, Shaw C.