General Information
-
DRAMP ID
- DRAMP02129
-
Peptide Name
- Kasstasin (Frogs, amphibians, animals)
-
Source
- Kassina maculata (African rhacophorid frog) (Hylambates maculatus)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
- Not found
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Sequence
- FIKELLPHLSGIIDSVANAIK
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Sequence Length
- 21
-
UniProt Entry
- G0LWV9
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.21624426]Gram-positive bacterium: Staphylococcus aureus (MIC=55 µM);
- Gram-negative bacterium: Escherichia coli (MIC=110 µM).
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Hemolytic Activity
-
- [Ref.21624426]12.8% hemolytic activity at 125 μM against defibrinated horse blood
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP02129_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C106H176N26O29
Absent Amino Acids
- CMQRTWY
Common Amino Acids
- I
Mass
- 2278.72
PI
- 6.75
Basic Residues
- 3
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- +1
-
Boman Index
- 1.29
Hydrophobicity
- 0.71
Aliphatic Index
- 153.33
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP02129
Comments Information
Function
- Peptide with potent vasoconstrictor properties. Has moderate antimicrobial activity. Not active against fungus C. albicans. Has hemolytic activity against horse erythrocytes.
Tissue specificity
- Expressed by the skin dorsal glands.
Miscellaneous
- Kasstasin is a derivation of Kassina, the taxon of origin, and the Ancient Greek word 'stasis' meaning 'stoppage of flow'.
Literature Information
- ·Literature 1
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Title
- Kasstasin: A novel potent vasoconstrictor peptide from the skin secretion of the African red-legged running frog, Kassina maculata.
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Pubmed ID
- 21624426
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Reference
- Biochimie. 2011 Sep;93(9):1537-1542.
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Author
- Li X, Feng W, Zhou M, Ma C, Chen T, Zeller M, Hornshaw M, Wang L, Shaw C.