General Information

    • DRAMP ID

    • DRAMP02131

    • Peptide Name

    • Antimicrobial peptide 2 (XT-2; Frogs, amphibians, animals)

    • Source

    • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVWSTVLGGLKKFAKGGLEAIVNPK

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC>100 µM);
      • Gram-negative bacteria: Escherichia coli (MIC=8 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02131 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02131.

Physicochemical Information

    • Formula

    • C120H197N31O31

    • Absent Amino Acids

    • CDHMQRY

    • Common Amino Acids

    • G

    • Mass

    • 2570.07

    • PI

    • 10

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • 3.81

    • Hydrophobicity

    • 0.252

    • Aliphatic Index

    • 105.2

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 229.17

    • Polar Residues

    • 8

DRAMP02131

DRAMP02131 chydropathy plot

Comments Information

    • Function

    • Has very strong antibacterial activity against Gram-positive bacterium S. aureus and very weak activity against Gram-negative bacterium E. coli.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).

    • Reference

    • Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.

    • Author

    • Ali MF, Soto A, Knoop FC, Conlon JM.