General Information
-
DRAMP ID
- DRAMP02132
-
Peptide Name
- Antimicrobial peptide 3 (XT-3; Levitide-like peptide; Frogs, amphibians, animals)
-
Source
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
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Family
- Belongs to the gastrin/cholecystokinin family (Magainin subfamily)
-
Gene
- Not found
-
Sequence
- GLASTLGSFLGKFAKGGAQAFLQPK
-
Sequence Length
- 25
-
UniProt Entry
- P84383
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus;
- Gram-negative bacteria: E.coli (Combination with XT1 and XT6).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02132.
Physicochemical Information
-
Formula
- C116H184N30O31
Absent Amino Acids
- CDEHIMNRVWY
Common Amino Acids
- G
Mass
- 2494.92
PI
- 10.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- 3.46
Hydrophobicity
- 0.248
Aliphatic Index
- 78.4
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 8
DRAMP02132
Comments Information
Function
- Has antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli, when in combination with XT1 and XT6.
Literature Information
- ·Literature 1
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Title
- Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).
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Pubmed ID
- 11738090
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Reference
- Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.
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Author
- Ali MF, Soto A, Knoop FC, Conlon JM.