General Information

    • DRAMP ID

    • DRAMP02153

    • Peptide Name

    • Hemolytic protein A1 (Frogs, amphibians, animals)

    • Source

    • Rana esculenta (Edible frog) (Pelophylax esculentus)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLPAIAGILSQLF

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.11738090]5% hemolytic activity at 1 nmol/ml, 20% hemolytic activity at 1.5nmol/ml, 30% hemolytic activity at 2nmol/ml, 60% hemolytic activity at 2.5nmol/ml, 88% hemolytic activity at 3nmol/ml, 95% hemolytic activity at 3.5nmol/ml against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02153 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02153.

Physicochemical Information

    • Formula

    • C69H108N14O16

    • Absent Amino Acids

    • CDEHKMNRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1389.7

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • 0

    • Boman Index

    • 26.18

    • Hydrophobicity

    • 1.792

    • Aliphatic Index

    • 165.38

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP02153

Comments Information

    • Function

    • Amphibian defensive peptide. Shows hemolytic activity.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of bioactive peptides from skin extracts of Rana esculenta.

    • Reference

    • Biochim Biophys Acta. 1990 Mar 26;1033(3):318-323.

    • Author

    • Simmaco M, De Biase D, Severini C, Aita M, Erspamer GF, Barra D, Bossa F.