General Information

    • DRAMP ID

    • DRAMP02171

    • Peptide Name

    • Tryptophyllin-T2-5 (Pha-T2-5; Tryptophyllin-1; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusahypochondrialis azurea)

    • Family

    • Belongs to the frog skin active peptide family (Tryptophillin subfamily)

    • Gene

    • Not found

    • Sequence

    • LPPWIG

    • Sequence Length

    • 6

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02171 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02171.

Physicochemical Information

    • Formula

    • C35H51N7O7

    • Absent Amino Acids

    • ACDEFHKMNQRSTVY

    • Common Amino Acids

    • P

    • Mass

    • 681.83

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • 0

    • Boman Index

    • 13.11

    • Hydrophobicity

    • 0.633

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 1100

    • Polar Residues

    • 1

DRAMP02171

Comments Information

    • Function

    • Amphibian defensive peptide.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Amphibian skin secretomics: application of parallel quadrupole time-of-flight mass spectrometry and peptide precursor cDNA cloning to rapidly characterize the skin secretory peptidome of Phyllomedusa hypochondrialis azurea: discovery of a novel peptide family, the hyposins.

    • Reference

    • J Proteome Res. 2007 Sep;6(9):3604-3613.

    • Author

    • Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.