General Information

    • DRAMP ID

    • DRAMP02177

    • Peptide Name

    • Tryptophyllin-T3-2 (Pj-T3-2; Frogs, amphibians, animals)

    • Source

    • Phasmahyla jandaia (Jandaia leaf frog)

    • Family

    • Belongs to the frog skin active peptide family (Tryptophillin subfamily)

    • Gene

    • Not found

    • Sequence

    • QDKPFWSPPIYPH

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02177 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02177.

Physicochemical Information

    • Formula

    • C79H106N18O19

    • Absent Amino Acids

    • ACEGLMNRTV

    • Common Amino Acids

    • P

    • Mass

    • 1611.82

    • PI

    • 6.74

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +1

    • Boman Index

    • -17.78

    • Hydrophobicity

    • -1.246

    • Aliphatic Index

    • 30

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 582.5

    • Polar Residues

    • 2

DRAMP02177

Comments Information

    • Function

    • Amphibian defensive peptide.

    • PTM

    • Pyrrolidone carboxylic acid at Q1.

    • Note

    • Sequence uncertainty at position 3 (K or Q) and 10 (I or L).

Literature Information

  • ·Literature 1

    • Title

    • Peptidomic dissection of the skin secretion of Phasmahyla jandaia (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).

    • Reference

    • Toxicon. 2011 Jan;57(1):35-52.

    • Author

    • Rates B, Silva LP, Ireno IC, Leite FS, Borges MH, Bloch C Jr, De Lima ME, Pimenta AM.