General Information

    • DRAMP ID

    • DRAMP02206

    • Peptide Name

    • Ranatuerin 2CHa (Frogs, amphibians, animals)

    • Source

    • Rana chiricahuensis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RGADEDDGVEITEEEVKRGLMDTVKNAAKNLAGQLLDRLKCKITGC

    • Sequence Length

    • 46

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.21262304] LC50=135 µM against human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys41 and Cys46)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys41 and Cys46.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02206 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02206.

Physicochemical Information

    • Formula

    • C208H357N63O73S3

    • Absent Amino Acids

    • FHPSWY

    • Common Amino Acids

    • DEGKL

    • Mass

    • 5004.68

    • PI

    • 4.89

    • Basic Residues

    • 8

    • Acidic Residues

    • 10

    • Hydrophobic Residues

    • 14

    • Net Charge

    • -2

    • Boman Index

    • -113.28

    • Hydrophobicity

    • -0.607

    • Aliphatic Index

    • 86.96

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 2.78

    • Polar Residues

    • 12

DRAMP02206

DRAMP02206 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.

    • Reference

    • J Mol Evol. 2007 Nov;65(5):605-615.

    • Author

    • Tennessen JA, Blouin MS.