• DRAMP ID

    • DRAMP02231
    • Peptide Name

    • Ranatuerin-4 (Frogs, amphibians, animals)
    • Source

    • Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLPFIARLAAKVFPSIICSVTKKC
    • Sequence Length

    • 24
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • [Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=55 µM).
    • Hemolytic Activity

      • [Ref.9784389] Have no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bridge between Cys18 and Cys24.
    • Stereochemistry

    • L
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02231 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02231.
    • Formula

    • C126H206N30O28S2
    • Absent Amino Acids

    • DEGHMNQWY
    • Common Amino Acids

    • AFIK
    • Mass

    • 2653.33
    • PI

    • 9.85
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 13
    • Net Charge

    • +4
    • Boman Index

    • 8.67
    • Hydrophobicity

    • 1.108
    • Aliphatic Index

    • 117.92
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 5

DRAMP02231

DRAMP02231 chydropathy plot
    • Function

    • Antibacterial activity against Gram-positive bacterium S.aureus. Has no detectable hemolytic activity.
  • ·Literature 1
    • Title

    • Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana.
    • Reference

    • Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592.
    • Author

    • Goraya J, Knoop FC, Conlon JM.