• DRAMP ID

    • DRAMP02236
    • Peptide Name

    • Ranatuerin-9 (Frogs, amphibians, animals)
    • Source

    • Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLFPLITSFLSKVL
    • Sequence Length

    • 14
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antiviral
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=130 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02236 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02236.
    • Formula

    • C83H129N15O18
    • Absent Amino Acids

    • ACDEGHMNQRWY
    • Common Amino Acids

    • L
    • Mass

    • 1625.03
    • PI

    • 8.75
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +1
    • Boman Index

    • 22.66
    • Hydrophobicity

    • 1.75
    • Aliphatic Index

    • 160
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP02236

    • This peptide was found to be HIV active, EC50= 16.7 uM (Wang, G et al., 2010 Antimicrob Agents Chemother 54

    • 1343).
  • ·Literature 1
    • Title

    • Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana.
    • Reference

    • Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592.
    • Author

    • Goraya J, Knoop FC, Conlon JM.