General Information

    • DRAMP ID

    • DRAMP02237

    • Peptide Name

    • Ranatuerin-2Ya (Frogs, amphibians, animals)

    • Source

    • Not found

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLMDTIKGVAKTVAASWLDKLKCKITGC

    • Sequence Length

    • 28

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19254736] Gram-negative bacterium: Escherichia coli (MIC=50 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM).

    • Hemolytic Activity

      • [Ref.19254736] LC50>100 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02237 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C130H224N34O37S3

    • Absent Amino Acids

    • EFHNPQRY

    • Common Amino Acids

    • K

    • Mass

    • 2951.59

    • PI

    • 9.24

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -8.13

    • Hydrophobicity

    • 0.343

    • Aliphatic Index

    • 101.07

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 208.33

    • Polar Residues

    • 9

DRAMP02237

DRAMP02237 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Ranatuerin-2Ya showed appreciably greater cytolytic activity against HepG2 cells (LC(50)=20microM) than against erythrocytes (LC(50)>100microM).

Literature Information

  • ·Literature 1

    • Title

    • Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis.

    • Reference

    • Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.

    • Author

    • Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD.