General Information

    • DRAMP ID

    • DRAMP02243

    • Peptide Name

    • Ranatuerin-1T (Brevinin-2T; Frogs, amphibians, animals)

    • Source

    • Rana temporaria (European common frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLLSGLKKVGKHVAKNVAVSLMDSLKCKISGDC

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacterium: Staphylococcus aureus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02243 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02243.

Physicochemical Information

    • Formula

    • C147H260N42O43S3

    • Absent Amino Acids

    • EFPQRTWY

    • Common Amino Acids

    • K

    • Mass

    • 3400.12

    • PI

    • 9.51

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +5

    • Boman Index

    • -17.67

    • Hydrophobicity

    • 0.27

    • Aliphatic Index

    • 112.12

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.91

    • Polar Residues

    • 11

DRAMP02243

DRAMP02243 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Ranatuerin 1T: an antimicrobial peptide isolated from the skin of the frog, Rana temporaria.

    • Reference

    • Peptides. 1999;20(2):159-163.

    • Author

    • Goraya J, Knoop FC, Conlon JM.
  • ·Literature 2

    • Title

    • Antimicrobial peptides from amphibian skin: what do they tell us?

    • Reference

    • Biopolymers. 1998;47(6):435-450.

    • Author

    • Simmaco M, Mignogna G, Barra D.