General Information

    • DRAMP ID

    • DRAMP02249

    • Peptide Name

    • Ranatuerin-2SEB (Frogs, amphibians, animals)

    • Source

    • Rana sevosa (dusky gopher frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • AIMDTIKDTAKTVAVGLLNKLKCKITGC

    • Sequence Length

    • 28

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli K12;
      • Gram-positive bacterium: Micrococcus luteus NCT C2665.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02249 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02249.

Physicochemical Information

    • Formula

    • C128H230N34O38S3

    • Absent Amino Acids

    • EFHPQRSWY

    • Common Amino Acids

    • K

    • Mass

    • 2949.62

    • PI

    • 9.24

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -12.29

    • Hydrophobicity

    • 0.429

    • Aliphatic Index

    • 115

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.63

    • Polar Residues

    • 9

DRAMP02249

DRAMP02249 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa.

    • Reference

    • Peptides. 2006 Jun;27(6):1313-1319.

    • Author

    • Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C.