General Information

    • DRAMP ID

    • DRAMP02252

    • Peptide Name

    • Ranatuerin 2SKa (Frogs, amphibians, animals)

    • Source

    • Rana sakuraii (Japanese brown frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLLDAIKDTAQNLFANVLDKIKCKFTKC

    • Sequence Length

    • 28

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=50 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC>50 µM).
      • Yeast: Candida albicans (MIC>50 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys23 and Cys28)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys23 and Cys28.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02252 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02252.

Physicochemical Information

    • Formula

    • C139H232N36O40S2

    • Absent Amino Acids

    • EHMPRSWY

    • Common Amino Acids

    • K

    • Mass

    • 3111.71

    • PI

    • 8.79

    • Basic Residues

    • 5

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • -29.42

    • Hydrophobicity

    • 0.075

    • Aliphatic Index

    • 104.64

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.63

    • Polar Residues

    • 7

DRAMP02252

DRAMP02252 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.

    • Reference

    • Peptides. 2007 Mar;28(3):505-514.

    • Author

    • Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.