General Information

    • DRAMP ID

    • DRAMP02253

    • Peptide Name

    • Ranatuerin-IIbYb (Ranatuerin-2bYa; Frogs, amphibians, animals)

    • Source

    • Rana boylii (Foothill yellow-legged frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GIMDSVKGLAKNLAGKLLDSLKCKITGC

    • Sequence Length

    • 28

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02253 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02253.

Physicochemical Information

    • Formula

    • C124H222N34O37S3

    • Absent Amino Acids

    • EFHPQRWY

    • Common Amino Acids

    • KL

    • Mass

    • 2877.51

    • PI

    • 9.24

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • -10.43

    • Hydrophobicity

    • 0.314

    • Aliphatic Index

    • 115

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.63

    • Polar Residues

    • 10

DRAMP02253

DRAMP02253 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Isolation of peptides of the brevinin-2 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.

    • Reference

    • J Pept Res. 2003 Nov;62(5):207-213.

    • Author

    • Conlon JM, Sonnevend A, Patel M, Davidson C, Nielsen PF, Pál T, Rollins-Smith LA.