General Information

    • DRAMP ID

    • DRAMP02254

    • Peptide Name

    • Ranatuerin-2La (Ranatuerin 2La; Ranatuerin-2PRa; Frogs, amphibians, animals)

    • Source

    • Rana luteiventris (Spotted frog) (Rana pretiosa)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GILDSFKGVAKGVAKDLAGKLLDKLKCKITGC

    • Sequence Length

    • 32

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=11 µM);
      • Gram-negative bacterium: Escherichia coli (MIC=4 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02254 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C147H257N39O41S2

    • Absent Amino Acids

    • EHMNPQRWY

    • Common Amino Acids

    • K

    • Mass

    • 3291.01

    • PI

    • 9.45

    • Basic Residues

    • 7

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • -12.79

    • Hydrophobicity

    • 0.259

    • Aliphatic Index

    • 112.81

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.03

    • Polar Residues

    • 9

DRAMP02254

DRAMP02254 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.

    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.

    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.