General Information

    • DRAMP ID

    • DRAMP02258

    • Peptide Name

    • Ranatuerin-IIbYa (Ranatuerin-2bYa; Frogs, amphibians, animals)

    • Source

    • Rana boylii (Foothill yellow-legged frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GILSTFKGLAKGVAKDLAGNLLDKFKCKITGC

    • Sequence Length

    • 32

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.14531844]Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacterium: Staphylococcus aureus

    • Hemolytic Activity

      • [Ref.14531844]HC50=120 μM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02258 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02258.

Physicochemical Information

    • Formula

    • C149H253N39O41S2

    • Absent Amino Acids

    • EHMPQRWY

    • Common Amino Acids

    • K

    • Mass

    • 3311

    • PI

    • 9.51

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • -8.79

    • Hydrophobicity

    • 0.316

    • Aliphatic Index

    • 103.75

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.03

    • Polar Residues

    • 11

DRAMP02258

DRAMP02258 chydropathy plot

Comments Information

    • Function

    • Show weak hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.

    • Reference

    • J Pept Res. 2003 Nov;62(5):207-213.

    • Author

    • Conlon JM, Sonnevend A, Patel M, Davidson C, Nielsen PF, Pál T, Rollins-Smith LA.