General Information

    • DRAMP ID

    • DRAMP02269

    • Peptide Name

    • Antimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)

    • Source

    • Xenopus laevis (African clawed frog)

    • Family

    • Belongs to the magainin family

    • Gene

    • pgq

    • Sequence

    • GVLSNVIGYLKKLGTGALNAVLKQ

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=62-250 µg/ml), K. Pneumonae (MIC=125-250 µg/ml), Pseudomonas aeruginosa (MIC=250-500 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 µg/ml), Streptococcus faecalis (MIC=250-500 µg/ml).
      • Yeast: Candida albicans (MIC=250-500 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix(potential)

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02269 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02269.

Physicochemical Information

    • Formula

    • C112H194N30O31

    • Absent Amino Acids

    • CDEFHMPRW

    • Common Amino Acids

    • L

    • Mass

    • 2456.95

    • PI

    • 10

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • 7.44

    • Hydrophobicity

    • 0.546

    • Aliphatic Index

    • 142.08

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 64.78

    • Polar Residues

    • 9

DRAMP02269

DRAMP02269 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide.

    • Tissue specificity

    • Is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides in the stomach of Xenopus laevis.

    • Reference

    • J Biol Chem. 1991 Oct 15;266(29):19851-19857.

    • Author

    • Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M.