• • DRAMP ID

  • DRAMP02273

• • Peptide Name

  • PGLa-H (chain of PYLa/PGLa A; Frogs, amphibians, animals)

• • Source

  • Xenopus laevis (African clawed frog)

• • Family

  • Belongs to the gastrin/cholecystokinin family (Magainin subfamily)

• • Gene

  • pgla-a AND pgla-b

• • Sequence

  • KIAKVALKAL

• • Sequence Length

  • 10

• • UniProt Entry

  • Q99134,B7ZSG6,Q91826

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.22014884]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.7 µg/ml), Bacillus subtilis (MIC=14.4 µg/ml), Staphylococcus aureus (MRSA) (MIC=67.8 µg/ml);
    • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.6 µg/ml)

• • Hemolytic Activity

  • • [Ref.22014884]3.15% hemolytic activity at 100 μg/mL, 7.95% hemolytic activity at 200 μg/mL against rabbit red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP02273_predicted_structure.pdb to download.

DRAMP02273

• • Function

  • PGLa-H display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa-H shows moderate antibacterial activity against the multidrug-resistant methicillin-resistant S. aureus (MRSA) but exhibits hemolytic activity.

• • Tissue specificity

  • Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin.

• • PTM

  • Leucine amide at position 10.

• ·Literature 1

• • Title

  • Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis.

• • Pubmed ID

  • 22014884

• • Reference

  • Int J Antimicrob Agents. 2011 Dec;38(6):510-515.

• • Author

  • Hou F, Li J, Pan P, Xu J, Liu L, Liu W, Song B, Li N, Wan J, Gao H.

• ·Literature 2

• • Title

  • Antimicrobial peptides in the stomach of Xenopus laevis.

• • Pubmed ID

  • 1717472

• • Reference

  • J Biol Chem. 1991 Oct 15;266(29):19851-19857.

• • Author

  • Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M.