General Information
-
DRAMP ID
- DRAMP02276
-
Peptide Name
- Ranacyclin B3 (Frogs, amphibians, animals)
-
Source
- Odorrana grahami (Ranidae frogs)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- AALKGCWTKSIPPKPCSGKR
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
-
Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus (MIC=11.7 µM).
- Yeast: Candida albicans (MIC=23.4 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys6 and Cys16.
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02276.
Physicochemical Information
-
Formula
- C94H158N28O24S2
Absent Amino Acids
- DEFHMNQVY
Common Amino Acids
- K
Mass
- 2128.58
PI
- 10.07
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +5
-
Boman Index
- -26.26
Hydrophobicity
- -0.6
Aliphatic Index
- 49
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5625
Absorbance 280nm
- 296.05
Polar Residues
- 7
DRAMP02276
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins.
-
Pubmed ID
- 21927839
-
Reference
- Amino Acids. 2012 Jul;43(1):309-316.
-
Author
- Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R.