General Information

    • DRAMP ID

    • DRAMP02283

    • Peptide Name

    • Ranacyclin-B-LK2 (Frogs, amphibians, animals)

    • Source

    • Hylarana nigrovittata (Ranidae frogs)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • SALVGCWTKSWPPKPCFGR

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=11.8 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys6 and Cys16.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02283 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02283.

Physicochemical Information

    • Formula

    • C98H146N26O23S2

    • Absent Amino Acids

    • DEHIMNQY

    • Common Amino Acids

    • P

    • Mass

    • 2120.52

    • PI

    • 9.5

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -12.54

    • Hydrophobicity

    • -0.232

    • Aliphatic Index

    • 41.05

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11125

    • Absorbance 280nm

    • 618.06

    • Polar Residues

    • 7

DRAMP02283

DRAMP02283 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins.

    • Reference

    • Amino Acids. 2012 Jul;43(1):309-316.

    • Author

    • Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R.