General Information

    • DRAMP ID

    • DRAMP02285

    • Peptide Name

    • Pseudin-2 (Pseudin 2; Frogs, amphibians, animals)

    • Source

    • Pseudis paradoxa (Paradoxical frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLNALKKVFQGIHEAIKLINNHVQ

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.11689009]Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacterium: Staphylococcus aureus;
      • Yeast: Candida albicans

    • Hemolytic Activity

      • [Ref.11689009]50% hemolysis of human erythrocytes is >300 μM

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02285 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02285.

Physicochemical Information

    • Formula

    • C122H202N36O32

    • Absent Amino Acids

    • CDMPRSTWY

    • Common Amino Acids

    • IKLN

    • Mass

    • 2685.17

    • PI

    • 9.7

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +4

    • Boman Index

    • -17.7

    • Hydrophobicity

    • -0.008

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP02285

DRAMP02285 chydropathy plot

Comments Information

    • Function

    • Possesses antifungal activity against C. albicans and is also active against E. coli and S. aureus. Has low hemolytic activity against human erythrocytes.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog.

    • Reference

    • Biochem Biophys Res Commun. 2001 Nov 9;288(4):1001-1005.

    • Author

    • Olson L 4rd, Soto AM, Knoop FC, Conlon JM.