General Information

    • DRAMP ID

    • DRAMP02288

    • Peptide Name

    • Gaegurin-RN1 (Frogs, amphibians, animals)

    • Source

    • Rana nigrovittata

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FIGPVLKIAAGILPTAICKIFKKC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=2.34 µg/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 µg/ml), Bacillus subtilis (MIC=4.69 µg/ml);
      • Gram-negative bacterium: Escherichia coli ML-35P (MIC=18.75 µg/ml);
      • Yeast: Candida albicans ATCC2002 (MIC=4.69 µg/ml)

    • Hemolytic Activity

      • [Ref.19778602] It has 46.13 ± 1.49% hemolytic activity at 100 μg/ml against rabbit red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys18 and Cys24.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02288 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C122H206N28O26S2

    • Absent Amino Acids

    • DEHMNQRSWY

    • Common Amino Acids

    • I

    • Mass

    • 2545.27

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • 29.54

    • Hydrophobicity

    • 1.25

    • Aliphatic Index

    • 138.33

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 5

DRAMP02288

DRAMP02288 chydropathy plot

Comments Information

    • Function

    • Has hemolytic activity against rabbit red cells..

Literature Information

  • ·Literature 1

    • Title

    • Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.

    • Reference

    • Genomics. 2010 Jan;95(1):66-71.

    • Author

    • Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R.