General Information

    • DRAMP ID

    • DRAMP02306

    • Peptide Name

    • Riparin-2.1 (Frogs, amphibians, animals)

    • Source

    • Crinia riparia (Streambank froglet) (Flinders Ranges froglet)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IIEKLVNTALGLLSGL

    • Sequence Length

    • 16

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Lactococcus lactis (MIC=25 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02306 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02306.

Physicochemical Information

    • Formula

    • C76H136N18O22

    • Absent Amino Acids

    • CDFHMPQRWY

    • Common Amino Acids

    • L

    • Mass

    • 1654.02

    • PI

    • 6

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • 0

    • Boman Index

    • 17.2

    • Hydrophobicity

    • 1.3

    • Aliphatic Index

    • 195

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP02306

Comments Information

    • Function

    • Has antibacterial activity. Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli, and against the Gram-positive bacteria B. cereus, E. faecalis, L. innocua, M. luteus, S. aureus, S. epidermidis and S. uberis. Does not inhibit the formation of NO by neuronal nitric oxide synthase.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Host-defence skin peptides of the Australian streambank froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry.

    • Reference

    • Rapid Commun Mass Spectrom. 2006;20(5):797-803.

    • Author

    • Maselli VM, Bilusich D, Bowie JH, Tyler MJ.