General Information

    • DRAMP ID

    • DRAMP02307

    • Peptide Name

    • Deserticolin-1 (Frogs, amphibians, animals)

    • Source

    • Crinia deserticola (Desert froglet)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLADFLNKAVGKVVDFVKS

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Leuconostoc lactis (MIC=25 µM), Streptococcus uberis (MIC=50 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02307 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02307.

Physicochemical Information

    • Formula

    • C93H151N23O26

    • Absent Amino Acids

    • CEHIMPQRTWY

    • Common Amino Acids

    • V

    • Mass

    • 2007.36

    • PI

    • 8.5

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • -6.67

    • Hydrophobicity

    • 0.516

    • Aliphatic Index

    • 112.63

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02307

DRAMP02307 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity against the Gram-positive bacteria. Inhibits the formation of NO by neuronal nitric oxide synthase with an IC50 of 2.4 µM.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: structure, activity and evolutionary trends.

    • Reference

    • Regul Pept. 2008 Nov 29;151(1-3):80-87.

    • Author

    • Jackway RJ, Pukala TL, Maselli VM, Musgrave IF, Bowie JH, Liu Y, Surinya-Johnson KH, Donnellan SC, Doyle JR, Llewellyn LE, Tyler MJ.