General Information

    • DRAMP ID

    • DRAMP02313

    • Peptide Name

    • Hepcidin-1 (fish, chordates, animals)

    • Source

    • Salmo salar (Atlantic salmon)

    • Family

    • Belongs to the hepcidin family

    • Gene

    • hamp1

    • Sequence

    • QIHLSLCGLCCNCCHNIGCGFCCKF

    • Sequence Length

    • 25

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02313 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02313.

Physicochemical Information

    • Formula

    • C112H175N33O30S8

    • Absent Amino Acids

    • ADEMPRTVWY

    • Common Amino Acids

    • C

    • Mass

    • 2720.3

    • PI

    • 7.73

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • 6.53

    • Hydrophobicity

    • 0.928

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 500

    • Absorbance 280nm

    • 20.83

    • Polar Residues

    • 14

DRAMP02313

DRAMP02313 chydropathy plot

Comments Information

    • Function

    • Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.

    • PTM

    • Contains four disulfide bonds 7-23; 10-13; 11-19; 14-22.

Literature Information

  • ·Literature 1

    • Title

    • Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish.

    • Reference

    • Dev Comp Immunol. 2003 Jun-Jul;27(6-7):589-601.

    • Author

    • Douglas SE, Gallant JW, Liebscher RS, Dacanay A, Tsoi SC.