General Information

    • DRAMP ID

    • DRAMP02319

    • Peptide Name

    • Grammistin Pp2a (Group II grammistin; fish, chordates, animals)

    • Source

    • Pogonoperca punctata (Clown grouper) (Bearded grouper)

    • Family

    • Belongs to the grammistin family (Group 2 subfamily)

    • Gene

    • Not found

    • Sequence

    • FIGGIISLIKKLF

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Swiss_Prot Entry P69843]has lytic, hemolytic and antibacterial activities

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Phospholipids

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02319 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02319.

Physicochemical Information

    • Formula

    • C73H121N15O15

    • Absent Amino Acids

    • ACDEHMNPQRTVWY

    • Common Amino Acids

    • I

    • Mass

    • 1448.86

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • 22.86

    • Hydrophobicity

    • 1.677

    • Aliphatic Index

    • 180

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP02319

Comments Information

    • Function

    • Has lytic, hemolytic and antibacterial activities.

Literature Information

  • ·Literature 1

    • Title

    • Primary and secondary structures of grammistins, peptide toxins isolated from the skin secretion of the soapfish Pogonoperca punctata.

    • Reference

    • Fish. Sci. 2001 Feb;67:163-169.

    • Author

    • Shiomi K, Yokota H, Nagashima Y, Ishida M.