General Information

    • DRAMP ID

    • DRAMP02323

    • Peptide Name

    • Grammistin Pp4b (Group I grammistin; fish, chordates, animals)

    • Source

    • Pogonoperca punctata (Clown grouper) (Bearded grouper)

    • Family

    • Belongs to the grammistin family (Group 1 subfamily)

    • Gene

    • Not found

    • Sequence

    • LFGFLIPLLPHLIGAIPQVIGAIR

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Phospholipids

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02323 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02323.

Physicochemical Information

    • Formula

    • C127H206N30O26

    • Absent Amino Acids

    • CDEKMNSTWY

    • Common Amino Acids

    • IL

    • Mass

    • 2569.22

    • PI

    • 9.76

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +2

    • Boman Index

    • 40.52

    • Hydrophobicity

    • 1.571

    • Aliphatic Index

    • 182.92

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP02323

DRAMP02323 chydropathy plot

Comments Information

    • MOA

    • Thanks to its abundant amphiphilic alpha-helices, it may integrate into membrane phospholipids, leading to lysis of the membrane. Has also ichthyotoxic activity.

Literature Information

  • ·Literature 1

    • Title

    • Primary and secondary structures of grammistins, peptide toxins isolated from the skin secretion of the soapfish Pogonoperca punctata.

    • Reference

    • Fish. Sci. 2001 Feb;67:163-169.

    • Author

    • Shiomi K, Yokota H, Nagashima Y, Ishida M.