General Information

    • DRAMP ID

    • DRAMP02324

    • Peptide Name

    • SAMP H1 (fish, chordates, animals)

    • Source

    • Salmo salar (Atlantic salmon)

    • Family

    • Belongs to the histone H1/H5 family

    • Gene

    • Not found

    • Sequence

    • AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS

    • Sequence Length

    • 30

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=2 µM), Aeromonas salmonicida subsp salmonicida (MIC=4 µM), Vibrio anguillarum (MIC=1 µM) Salmonella typhimurium (MIC=4 µM);
      • Gram-positive bacteria: Bacillus subtilis (MIC=2 µM), Listeria ivanovii (MIC=4 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02324 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02324.

Physicochemical Information

    • Formula

    • C126H217N37O34

    • Absent Amino Acids

    • CDFHILMNQRTWY

    • Common Amino Acids

    • A

    • Mass

    • 2794.34

    • PI

    • 10.4

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +6

    • Boman Index

    • -20.55

    • Hydrophobicity

    • -0.467

    • Aliphatic Index

    • 53

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP02324

DRAMP02324 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Proline conformation-dependent antimicrobial activity of a proline-rich histone H1 N-terminal peptide fragment isolated from the skin mucus of Atlantic salmon.

    • Reference

    • Antimicrob Agents Chemother. 2005 Jun;49(6):2399-2406.

    • Author

    • Luders T, Birkemo G.A, Nissen-Meyer J, Andersen O, Nes I.F.