General Information

    • DRAMP ID

    • DRAMP02327

    • Peptide Name

    • Moronecidin 3 (fish, chordates, animals)

    • Source

    • Morone chrysops (white bass)

    • Family

    • Belongs to the pleurocidin family

    • Gene

    • Not found

    • Sequence

    • FFHHIFRGIVHVGRTIHKLVTGG

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02327 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02327.

Physicochemical Information

    • Formula

    • C124H190N38O26

    • Absent Amino Acids

    • ACDEMNPQSWY

    • Common Amino Acids

    • GH

    • Mass

    • 2629.11

    • PI

    • 12.01

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +7

    • Boman Index

    • -14.67

    • Hydrophobicity

    • 0.417

    • Aliphatic Index

    • 105.65

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP02327

DRAMP02327 chydropathy plot

Comments Information

    • Function

    • Exhibits antimicrobial activity against fish bacterial pathogens, especially against species of Aeromonas, which may to certain extent reflect the pathogenicity of these bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass.

    • Reference

    • J Biol Chem. 2002 Feb 15;277(7):5030-5039.

    • Author

    • Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P.