General Information

    • DRAMP ID

    • DRAMP02332

    • Peptide Name

    • Piscidin-3 (Pis-3; fish, chordates, animals)

    • Source

    • Morone chrysops x Morone saxatilis (white bass x striped sea-bass)

    • Family

    • Belongs to the pleurocidin family

    • Gene

    • Not found

    • Sequence

    • FIHHIFRGIVHAGRSIGRFLTG

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral

    • Target Organism

    • [Swiss_Prot Entry P0C006]broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria

    • Hemolytic Activity

      • [Ref.11713517]5% hemolytic activity at 100 μg/mL against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02332 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02332.

Physicochemical Information

    • Formula

    • C116H179N37O25

    • Absent Amino Acids

    • CDEKMNPQWY

    • Common Amino Acids

    • GI

    • Mass

    • 2491.93

    • PI

    • 12.3

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +6

    • Boman Index

    • -21.56

    • Hydrophobicity

    • 0.455

    • Aliphatic Index

    • 106.36

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP02332

DRAMP02332 chydropathy plot

Comments Information

    • Function

    • Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has hemolytic activity.

    • Tissue specificity

    • Mast cells in gill, skin and gut, and in lining blood vessels in the viscera.

Literature Information

  • ·Literature 1

    • Title

    • Peptide antibiotics in mast cells of fish.

    • Reference

    • Nature. 2001 Nov 15;414(6861):268-269.

    • Author

    • Silphaduang U, Noga EJ.