General Information
-
DRAMP ID
- DRAMP02334
-
Peptide Name
- Hepcidin (fish, chordates, animals)
-
Source
- Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
-
Family
- Belongs to the hepcidin family
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Gene
- hamp
-
Sequence
- XSHLSLCRWCCNCCHNKGXGFCCKF
-
Sequence Length
- 25
-
UniProt Entry
- Q9DFD6
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02334.
Physicochemical Information
-
Formula
- C110H161N35O26S7
Absent Amino Acids
- ADEIMPQTVY
Common Amino Acids
- C
Mass
- 2872.82
PI
- 8.6
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +5
-
Boman Index
- -26.45
Hydrophobicity
- 0.068
Aliphatic Index
- 31.2
Half Life
-
- Mammalian:?
- Yeast:?
- E.coli:?
Extinction Coefficient Cystines
- 5875
Absorbance 280nm
- 244.79
Polar Residues
- 13
DRAMP02334
Comments Information
Function
- Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.
PTM
- Contains four disulfide bonds 7-23; 10-13; 11-19; 14-22.
Literature Information
- ·Literature 1
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Title
- Immune-relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive hybridization.
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Pubmed ID
- 11164886
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Reference
- Dev Comp Immunol. 2001 Apr;25(3):205-217.
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Author
- Bayne CJ, Gerwick L, Fujiki K, Nakao M, Yano T.