• DRAMP ID

    • DRAMP02336
    • Peptide Name

    • Oncorhyncin II (Oncorhyncin 2; fish, chordates, animals)
    • Source

    • Oncorhynchus mykiss (Rainbow trout)
    • Family

    • Belongs to the histone H1/H5 family
    • Gene

    • Not found
    • Sequence

    • KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK
    • Sequence Length

    • 69
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacteria: Planococcus citreus (MIC=0.2-0.4 µM), Micrococcus luteus (MIC=0.2-0.4 µM);
      • Gram-negative bacteria: Escherichia coli (MIC=0.4-0.8 µM), Listonella anguillarum (MIC=0.4-0.8 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02336 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02336.
    • Formula

    • C321H587N99O75
    • Absent Amino Acids

    • CDEFGHILMNQRWY
    • Common Amino Acids

    • K
    • Mass

    • 7033.81
    • PI

    • 11.46
    • Basic Residues

    • 30
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 25
    • Net Charge

    • +30
    • Boman Index

    • -132.13
    • Hydrophobicity

    • -1.238
    • Aliphatic Index

    • 41.74
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 5

DRAMP02336

DRAMP02336 chydropathy plot
    • Potentially important role in mucosal defense.

  • ·Literature 1
    • Title

    • Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss.
    • Reference

    • Dev Comp Immunol. 2004 Feb;28(2):127-138.
    • Author

    • Fernandes JM, Molle G, Kemp GD, Smith VJ.