General Information
-
DRAMP ID
- DRAMP02336
-
Peptide Name
- Oncorhyncin II (Oncorhyncin 2; fish, chordates, animals)
-
Source
- Oncorhynchus mykiss (Rainbow trout)
-
Family
- Belongs to the histone H1/H5 family
-
Gene
- Not found
-
Sequence
- KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK
-
Sequence Length
- 69
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Planococcus citreus (MIC=0.2-0.4 µM), Micrococcus luteus (MIC=0.2-0.4 µM);
- Gram-negative bacteria: Escherichia coli (MIC=0.4-0.8 µM), Listonella anguillarum (MIC=0.4-0.8 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02336.
Physicochemical Information
-
Formula
- C321H587N99O75
Absent Amino Acids
- CDEFGHILMNQRWY
Common Amino Acids
- K
Mass
- 7033.81
PI
- 11.46
Basic Residues
- 30
Acidic Residues
- 0
Hydrophobic Residues
- 25
Net Charge
- +30
-
Boman Index
- -132.13
Hydrophobicity
- -1.238
Aliphatic Index
- 41.74
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP02336
Comments Information
Potentially important role in mucosal defense.
Literature Information
- ·Literature 1
-
Title
- Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss.
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Pubmed ID
- 12969798
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Reference
- Dev Comp Immunol. 2004 Feb;28(2):127-138.
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Author
- Fernandes JM, Molle G, Kemp GD, Smith VJ.