General Information

    • DRAMP ID

    • DRAMP02337

    • Peptide Name

    • Oncorhyncin III (Oncorhyncin 3; fish, chordates, animals)

    • Source

    • Oncorhynchus mykiss (Rainbow trout)

    • Family

    • Belongs to the HMGN family

    • Gene

    • Not found

    • Sequence

    • PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG

    • Sequence Length

    • 66

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Aerococcus viridans (MIC=0.06-0.12 µM), Bacillus subtilis (MIC=0.25-0.5 µM), Micrococcus luteus (MIC=0.12-0.25 µM), Planococcus citreus (MIC=0.06-0.12 µM);
      • Gram-negative bacteria: Aeromonas hydrophila (MIC>0.5 µM), Aeromonas salmonicida 004 (MIC>0.5 µM), Escherichia coli (MIC=0.25-0.5 µM), Listonella anguillarum (MIC=0.25-0.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • DNA

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02337 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02337.

Physicochemical Information

    • Formula

    • C285H497N97O85

    • Absent Amino Acids

    • CFHIMWY

    • Common Amino Acids

    • A

    • Mass

    • 6642.68

    • PI

    • 10.72

    • Basic Residues

    • 19

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 22

    • Net Charge

    • +13

    • Boman Index

    • -168.58

    • Hydrophobicity

    • -1.106

    • Aliphatic Index

    • 46.36

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 11

DRAMP02337

DRAMP02337 chydropathy plot

Comments Information

    • Plays a role in mucosal innate host defence.

Literature Information

  • ·Literature 1

    • Title

    • Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss.

    • Reference

    • Biochem J. 2003 Jul 15;373(Pt 2):621-628.

    • Author

    • Fernandes J.M.O, Saint N, Kemp G.D, Smith V.J.