General Information

    • DRAMP ID

    • DRAMP02347

    • Peptide Name

    • NRC-1 (fish, chordates, animals)

    • Source

    • Pseudopleuronectes americanus (Winter flounder 1)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GKGRWLERIGKAGGIIIGGALDHL

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 µg/ml), Aeromonas salmonicida 97-4 (MIC=64 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 µg/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 µg/ml), Pseudomonas aeruginosa K799 (MIC>64 µg/ml), Pseudomonas aeruginosa Z61 (MIC=32 µg/ml), Escherichia coli CGSC 4908 (MIC=32 µg/ml), Escherichia coli UB1005 (MIC=32 µg/ml), Escherichia coli DC2 (MIC=32 µg/ml);
      • Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 µg/ml).
      • Yeast: Candida albicans C627 (MIC=64 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02347 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C112H187N35O29

    • Absent Amino Acids

    • CFMNPQSTVY

    • Common Amino Acids

    • G

    • Mass

    • 2487.93

    • PI

    • 9.99

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • -14.16

    • Hydrophobicity

    • 0.096

    • Aliphatic Index

    • 122.08

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 239.13

    • Polar Residues

    • 7

DRAMP02347

DRAMP02347 chydropathy plot

Comments Information

    • C-terminal NH2, this NRC seris of peptides was identified by gene analysis and biological activity verified using synthetic peptides.

Literature Information

  • ·Literature 1

    • Title

    • Novel antimicrobial peptides derived from flatfish genes.

    • Reference

    • Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.

    • Author

    • Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.