General Information
-
DRAMP ID
- DRAMP02352
-
Peptide Name
- NRC-16 (fish, chordates, animals)
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Source
- Glyptocephalus cynoglossus (Witch flounder GC3.8-t)
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Family
- Not found
-
Gene
- Not found
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Sequence
- GWKKWLRKGAKHLGQAAIK
-
Sequence Length
- 19
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 µg/ml), A. salmonicida 97-4 (MIC=1 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=0.5 µg/ml), S. enterica serovar Typhimurium 14028s (MIC=16 µg/ml), Pseudomonas aeruginosa K799 (MIC=4 µg/ml), Pseudomonas aeruginosa Z61 (MIC=1 µg/ml), Escherichia coli CGSC 4908 (MIC=1 µg/ml), E. coli UB1005 (MIC=2 µg/ml), E. coli DC2 (MIC=0.5 µg/ml);
- Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 µg/ml).
- Yeast: Candida albicans C627 (MIC=8 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02352.
Physicochemical Information
-
Formula
- C102H166N32O21
Absent Amino Acids
- CDEFMNPSTVY
Common Amino Acids
- K
Mass
- 2176.64
PI
- 11.39
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +7
-
Boman Index
- -25.2
Hydrophobicity
- -0.853
Aliphatic Index
- 77.37
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 611.11
Polar Residues
- 3
DRAMP02352

Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Novel antimicrobial peptides derived from flatfish genes.
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Pubmed ID
- 12878506
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Reference
- Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.
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Author
- Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.