General Information

    • DRAMP ID

    • DRAMP02354

    • Peptide Name

    • Pleurocidin-like peptide WFY (fish, chordates, animals)

    • Source

    • Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FFRLLFHGVHHGGGYLNAA

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Aeromonas salmonicida A449 field isolate (MIC>64 µg/ml), A. salmonicida 97-4 field isolate (MIC>64 µg/ml), Pseudomonas aeruginosa K799 (MIC>64 µg/ml), Pseudomonas aeruginosa Z61 (MIC=64 µg/ml), Escherichia coli CGSC4908 triple (MIC=64 µg/ml), Salmonella typhimurium 14028s (MIC>64 µg/ml), Salmonella typhimurium MS7953s (MIC=64 µg/ml);
      • Gram-positive bacteria: Staphylococcus epidermidis (human clinical isolates) (MIC>64 µg/ml), Staphylococcus aureus (MRSA) (MIC>64 µg/ml).
      • Fungi: Candida albica (MIC>64 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02354 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02354.

Physicochemical Information

    • Formula

    • C101H141N29O22

    • Absent Amino Acids

    • CDEIKMPQSTW

    • Common Amino Acids

    • G

    • Mass

    • 2113.41

    • PI

    • 8.77

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +4

    • Boman Index

    • -0.56

    • Hydrophobicity

    • 0.374

    • Aliphatic Index

    • 87.37

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 82.78

    • Polar Residues

    • 6

DRAMP02354

DRAMP02354 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Identification, structure and differential expression of novel pleurocidins clustered on the genome of the winter flounder, Pseudopleuronectes americanus (Walbaum).

    • Reference

    • Eur J Biochem. 2003 Sep;270(18):3720-3730.

    • Author

    • Douglas SE, Patrzykat A, Pytyck J, Gallant JW.