General Information
-
DRAMP ID
- DRAMP02364
-
Peptide Name
- Pleurocidin-like peptide GcSc4B7 (NRC-15; fish, chordates, animals; Predicted)
-
Source
- Glyptocephalus cynoglossus (Witch flounder GcSc4B7)
-
Family
- Not found
-
Gene
- ple
-
Sequence
- GFWGKLFKLGLHGIGLLHLHL
-
Sequence Length
- 21
-
UniProt Entry
- Q7SZG9
-
Protein Existence
- Predicted
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 µg/ml), A. salmonicida 97-4 (MIC=16 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 µg/ml), S. enterica serovar Typhimurium 14028s (MIC=16 µg/ml), Pseudomonas aeruginosa K799 (MIC=8 µg/ml), Pseudomonas aeruginosa Z61 (MIC=4 µg/ml), Escherichia coli CGSC 4908 (MIC=8 µg/ml), E. coli UB1005 (MIC=8 µg/ml), E. coli DC2 (MIC=8 µg/ml);
- Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 µg/ml).
- Yeast: Candida albicans C627 (MIC=16 µg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP02364_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C117H178N30O22
Absent Amino Acids
- ACDEMNPQRSTVY
Common Amino Acids
- L
Mass
- 2356.89
PI
- 10
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +5
-
Boman Index
- 27.27
Hydrophobicity
- 0.781
Aliphatic Index
- 148.57
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 275
Polar Residues
- 5
DRAMP02364
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Novel antimicrobial peptides derived from flatfish genes.
-
Pubmed ID
- 12878506
-
Reference
- Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.
-
Author
- Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.