General Information
-
DRAMP ID
- DRAMP02365
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Peptide Name
- Pleurocidin-like peptide GC3.8 (NRC-17; fish, chordates, animals; Predicted)
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Source
- Glyptocephalus cynoglossus (Witch flounder GC3.8)
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Family
- Not found
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Gene
- ple
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Sequence
- GWKKWLRKGAKHLGQAAIKGLAS
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Sequence Length
- 23
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UniProt Entry
- Q7SZG8
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Protein Existence
- Predicted
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 µg/ml), A. salmonicida 97-4 (MIC=1 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=1 µg/ml), S. enterica serovar Typhimurium 14028s (MIC=8 µg/ml), Pseudomonas aeruginosa K799 (MIC=4 µg/ml), Pseudomonas aeruginosa Z61 (MIC=2 µg/ml), Escherichia coli CGSC 4908 (MIC=1 µg/ml), E. coli UB1005 (MIC=4 µg/ml), E. coli DC2 (MIC=1 µg/ml);
- Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 µg/ml).
- Yeast: Candida albicans C627 (MIC=8 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP02365_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C116H190N36O26
Absent Amino Acids
- CDEFMNPTVY
Common Amino Acids
- K
Mass
- 2505.01
PI
- 11.39
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +7
-
Boman Index
- -20.93
Hydrophobicity
- -0.513
Aliphatic Index
- 85.22
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 500
Polar Residues
- 5
DRAMP02365
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Novel antimicrobial peptides derived from flatfish genes.
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Pubmed ID
- 12878506
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Reference
- Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.
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Author
- Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.