General Information

    • DRAMP ID

    • DRAMP02372

    • Peptide Name

    • Hepcidin-1 (zebrafish, chordates, animals)

    • Source

    • Danio rerio (Zebrafish) (Brachydanio rerio)

    • Family

    • Belongs to the hepcidin family

    • Gene

    • hamp1

    • Sequence

    • QSHLSLCRFCCKCCRNKGCGYCCKF

    • Sequence Length

    • 25

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02372 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02372.

Physicochemical Information

    • Formula

    • C118H188N38O31S8

    • Absent Amino Acids

    • ADEIMPTVW

    • Common Amino Acids

    • C

    • Mass

    • 2891.51

    • PI

    • 8.94

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +6

    • Boman Index

    • -42.35

    • Hydrophobicity

    • -0.056

    • Aliphatic Index

    • 31.2

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1990

    • Absorbance 280nm

    • 82.92

    • Polar Residues

    • 14

DRAMP02372

DRAMP02372 chydropathy plot

Comments Information

    • Function

    • Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.

    • PTM

    • Contains four disulfide bonds 7-23; 10-13; 11-19; 14-22.

Literature Information

  • ·Literature 1

    • Title

    • Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates.

    • Reference

    • Dev Comp Immunol. 2004 Jun;28(7-8):747-754.

    • Author

    • Shike H, Shimizu C, Lauth X, Burns JC.