General Information
-
DRAMP ID
- DRAMP02376
-
Peptide Name
- Grammistin Gs 1 (Grammistin Gs F; Group I grammistin; soapfish, chordates, animals)
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Source
- Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)
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Family
- Belongs to the grammistin family (Group 1 subfamily)
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Gene
- Not found
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Sequence
- LFGFLIKLIPSLFGALSNIGRNRNQ
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Sequence Length
- 25
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UniProt Entry
- P69835
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 µg/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 µg/ml);
- Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 µg/ml), Escherichia coli JCM 1649 (MIC=50 µg/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=12.5 µg/ml), Salmonella typhimurium S1 (MIC>50 µg/ml), S. putrefaciens IAM 1509 (MIC=12.5 µg/ml), Vibrio anguillarum NCIBM 829 (MIC=50 µg/ml), Vibrio parahaemolyticus (MIC=25 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP02376_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C130H210N36O32
Absent Amino Acids
- CDEHMTVWY
Common Amino Acids
- L
Mass
- 2789.32
PI
- 12.01
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +3
-
Boman Index
- -14.72
Hydrophobicity
- 0.456
Aliphatic Index
- 128.8
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 8
DRAMP02376
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Interaction of grammistins with lipids and their antibacterial activity.
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Pubmed ID
- PubMed ID is not available
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Reference
- Fish. Sci. 2001 Oct;67:928-933.
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Author
- Yokota H, Nagashima Y, Shiomi K.