General Information

    • DRAMP ID

    • DRAMP02385

    • Peptide Name

    • Hepcidin AS-hepc6 (fish, chordates, animals)

    • Source

    • Acanthopagrus schlegelii (Black porgy)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • CRFCCRCCPRMRGCGLCCRF

    • Sequence Length

    • 20

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Pdp11 (IC50=2.20 µM), 51M6 (IC50=14.61 µM), Bacillus subtilis CECT 35 (IC50=11.41 µM), Escherichia coli DH5α (IC50=18.66 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02385 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02385.

Physicochemical Information

    • Formula

    • C92H153N35O21S9

    • Absent Amino Acids

    • ADEHIKNQSTVWY

    • Common Amino Acids

    • C

    • Mass

    • 2373.99

    • PI

    • 9.01

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +5

    • Boman Index

    • -49.25

    • Hydrophobicity

    • 0.32

    • Aliphatic Index

    • 19.5

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 500

    • Absorbance 280nm

    • 26.32

    • Polar Residues

    • 10

DRAMP02385

DRAMP02385 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • The antimicrobial peptide hepcidin exerts an important role in the innate immunity against bacteria in the bony fish giltherad seabream.

    • Reference

    • Mol Immunol. 2008 Apr;45(8):2333-2342.

    • Author

    • Cuesta A, Meseguer J, Esteban MA.