• DRAMP ID

    • DRAMP02387
    • Peptide Name

    • Histone HIIb-3 (Antibacterial histone-like protein 3, HLP-3; catfishes, chordates, animals)
    • Source

    • Ictalurus punctatus (Channel catfish)
    • Family

    • Belongs to the histone H2B family
    • Gene

    • Not found
    • Sequence

    • PDPAKTAPKKKSKKAVT
    • Sequence Length

    • 17
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antifungal
    • Target Organism

    • Aeromonas hydrophila, Saprolegnia spp.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02387 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02387.
    • Formula

    • C80H143N23O23
    • Absent Amino Acids

    • CEFGHILMNQRWY
    • Common Amino Acids

    • K
    • Mass

    • 1795.16
    • PI

    • 10.3
    • Basic Residues

    • 6
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +5
    • Boman Index

    • -41.09
    • Hydrophobicity

    • -1.429
    • Aliphatic Index

    • 34.71
    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP02387

    • Function

    • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • ·Literature 1
    • Title

    • Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins.
    • Reference

    • Cell Mol Life Sci. 1998 May;54(5):467-475.
    • Author

    • Robinette D, Wada S, Arroll T, Levy MG, Miller WL, Noga EJ.