General Information

    • DRAMP ID

    • DRAMP02388

    • Peptide Name

    • Histone HIIb-1 (Antibacterial histone-like protein 1, HLP-1; catfishes, chordates, animals)

    • Source

    • Ictalurus punctatus (Channel catfish)

    • Family

    • Belongs to the histone H2B family

    • Gene

    • Not found

    • Sequence

    • PDPAKTAPKKGSKKAVTKXA

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • Aeromonas hydrophila, vibrio alginolyticus, Escherichia coli D31, Saprolegnia spp.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02388 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02388.

Physicochemical Information

    • Formula

    • C85H149N25O24

    • Absent Amino Acids

    • CEFHILMNQRWY

    • Common Amino Acids

    • K

    • Mass

    • 2034.62

    • PI

    • 10.3

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +5

    • Boman Index

    • -38.34

    • Hydrophobicity

    • -1.145

    • Aliphatic Index

    • 34.5

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02388

DRAMP02388 chydropathy plot

Comments Information

    • Function

    • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins.

    • Reference

    • Cell Mol Life Sci. 1998 May;54(5):467-475.

    • Author

    • Robinette D, Wada S, Arroll T, Levy MG, Miller WL, Noga EJ.